Longitudinal Observational Trial to Uncover Subtypes of Cancer Cachexia

Status: Recruiting
Location: See all (195) locations...
Intervention Type: Other, Procedure
Study Type: Observational
SUMMARY

This study evaluates cancer-related weight and muscle mass loss, symptoms, and physical function (cachexia) in patients undergoing treatment for colorectal, lung, or pancreatic cancer that cannot be removed by surgery (unresectable). Patients with these cancer types are at risk for developing cancer cachexia (CC), which is defined as weight loss, muscle loss, and fat loss due to cancer. CC has been associated with reduced physical performance, impaired quality of life, and poorer survival. Many studies that have evaluated treatments for cancer-related weight and muscle loss have aimed to treat all patients with weight loss exactly the same and, unfortunately, have not been successful. Like different cancer types, weight and muscle loss related to cancer may have different causes in different individuals and the best treatment strategy for this condition may not be a one-size-fits-all approach. Information gathered from this study may help researchers develop new diagnostic criteria for CC and design better treatments and clinical trials for cancer-related weight and muscle loss in the future to improve the quality of life in patients with advanced colorectal, lung, or pancreatic cancer.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Have a primary diagnosis of unresectable or stage IV 1) non-small cell lung cancer (NSCLC), 2) pancreatic adenocarcinoma, or 3) colorectal cancer

⁃ Note: Patients do not need to have cachexia to be eligible

• Plan to start first-line systemic anti-cancer therapy (chemotherapy, immunotherapy, targeted therapy, interventional clinical trial) in the next 6 weeks or has started first-line systemic therapy in the previous 6 weeks.

⁃ NOTE: Patients who received systemic anti-cancer therapy previously as part of adjuvant or neoadjuvant treatment and have since recurred are still eligible if such treatment ended \> 6 months prior to enrollment. Patients receiving concurrent radiation with systemic therapy or received local therapy alone (surgery, radiation therapy \[RT\]) prior to first line therapy remain eligible. Patients receiving maintenance treatment after first line therapy are not eligible

• Have an Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1 or 2

• Be able to understand, speak and read English

• Be 18 years of age or older

Locations
United States
Arkansas
Mercy Hospital Fort Smith
RECRUITING
Fort Smith
Colorado
Rocky Mountain Cancer Centers-Aurora
RECRUITING
Aurora
Boulder Community Foothills Hospital
RECRUITING
Boulder
Rocky Mountain Cancer Centers-Boulder
RECRUITING
Boulder
Rocky Mountain Cancer Centers - Centennial
RECRUITING
Centennial
Colorado Blood Cancer Institute
RECRUITING
Denver
Rocky Mountain Cancer Centers-Midtown
RECRUITING
Denver
Rocky Mountain Cancer Centers-Rose
RECRUITING
Denver
The Women's Imaging Center
RECRUITING
Denver
Rocky Mountain Cancer Centers - Swedish
RECRUITING
Englewood
The Melanoma and Skin Cancer Institute
RECRUITING
Englewood
Rocky Mountain Cancer Centers-Lakewood
RECRUITING
Lakewood
Rocky Mountain Cancer Centers-Littleton
RECRUITING
Littleton
Rocky Mountain Cancer Centers-Sky Ridge
RECRUITING
Lone Tree
Rocky Mountain Cancer Centers-Thornton
RECRUITING
Thornton
Washington, D.c.
MedStar Georgetown University Hospital
RECRUITING
Washington D.c.
Delaware
Beebe South Coastal Health Campus
RECRUITING
Millville
Christiana Care Health System-Christiana Hospital
RECRUITING
Newark
Helen F Graham Cancer Center
RECRUITING
Newark
Medical Oncology Hematology Consultants PA
RECRUITING
Newark
Beebe Health Campus
RECRUITING
Rehoboth Beach
Christiana Care Health System-Wilmington Hospital
RECRUITING
Wilmington
Georgia
Northside Hospital
RECRUITING
Atlanta
Northeast Georgia Medical Center Braselton
RECRUITING
Braselton
John B Amos Cancer Center
RECRUITING
Columbus
Northside Hospital - Duluth
RECRUITING
Duluth
Northeast Georgia Medical Center-Gainesville
RECRUITING
Gainesville
The Longstreet Clinic - Gainesville
RECRUITING
Gainesville
Northside Hospital - Gwinnett
RECRUITING
Lawrenceville
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
RECRUITING
Savannah
Memorial Health University Medical Center
RECRUITING
Savannah
Tift Regional Medical Center
RECRUITING
Tifton
South Georgia Medical Center/Pearlman Cancer Center
RECRUITING
Valdosta
Hawaii
Hawaii Cancer Care - Westridge
RECRUITING
‘aiea
Pali Momi Medical Center
RECRUITING
‘aiea
Queen's Cancer Center - Pearlridge
RECRUITING
‘aiea
The Queen's Medical Center - West Oahu
RECRUITING
‘ewa Beach
Hawaii Cancer Care Inc - Waterfront Plaza
RECRUITING
Honolulu
Kapiolani Medical Center for Women and Children
RECRUITING
Honolulu
Queen's Cancer Cenrer - POB I
RECRUITING
Honolulu
Queen's Cancer Center - Kuakini
RECRUITING
Honolulu
Queen's Medical Center
RECRUITING
Honolulu
Straub Clinic and Hospital
RECRUITING
Honolulu
Illinois
Advocate Good Shepherd Hospital
RECRUITING
Barrington
Illinois CancerCare-Bloomington
RECRUITING
Bloomington
Illinois CancerCare-Canton
RECRUITING
Canton
Memorial Hospital of Carbondale
RECRUITING
Carbondale
SIH Cancer Institute
RECRUITING
Carterville
Illinois CancerCare-Carthage
RECRUITING
Carthage
Centralia Oncology Clinic
RECRUITING
Centralia
Advocate Illinois Masonic Medical Center
RECRUITING
Chicago
AMG Crystal Lake - Oncology
RECRUITING
Crystal Lake
Carle at The Riverfront
RECRUITING
Danville
Cancer Care Specialists of Illinois - Decatur
RECRUITING
Decatur
Decatur Memorial Hospital
RECRUITING
Decatur
Illinois CancerCare-Dixon
RECRUITING
Dixon
Advocate Good Samaritan Hospital
RECRUITING
Downers Grove
Crossroads Cancer Center
RECRUITING
Effingham
Advocate Sherman Hospital
RECRUITING
Elgin
Illinois CancerCare-Eureka
RECRUITING
Eureka
Illinois CancerCare-Galesburg
RECRUITING
Galesburg
Advocate South Suburban Hospital
RECRUITING
Hazel Crest
Illinois CancerCare-Kewanee Clinic
RECRUITING
Kewanee
AMG Libertyville - Oncology
RECRUITING
Libertyville
Condell Memorial Hospital
RECRUITING
Libertyville
Illinois CancerCare-Macomb
RECRUITING
Macomb
Carle BroMenn Medical Center
RECRUITING
Normal
Cancer Care Center of O'Fallon
RECRUITING
O'fallon
HSHS Saint Elizabeth's Hospital
RECRUITING
O'fallon
Advocate Christ Medical Center
RECRUITING
Oak Lawn
Advocate Outpatient Center - Oak Lawn
RECRUITING
Oak Lawn
Illinois CancerCare-Ottawa Clinic
RECRUITING
Ottawa
Advocate Lutheran General Hospital
RECRUITING
Park Ridge
Illinois CancerCare-Pekin
RECRUITING
Pekin
Illinois CancerCare-Peoria
RECRUITING
Peoria
Methodist Medical Center of Illinois
RECRUITING
Peoria
Illinois CancerCare-Peru
RECRUITING
Peru
Valley Radiation Oncology
RECRUITING
Peru
Illinois CancerCare-Princeton
RECRUITING
Princeton
Southern Illinois University School of Medicine
RECRUITING
Springfield
Springfield Clinic
RECRUITING
Springfield
Springfield Memorial Hospital
RECRUITING
Springfield
Carle Cancer Center
RECRUITING
Urbana
Illinois CancerCare - Washington
RECRUITING
Washington
Indiana
Reid Health
RECRUITING
Richmond
Maryland
Christiana Care - Union Hospital
RECRUITING
Elkton
Michigan
Corewell Health Grand Rapids Hospitals - Butterworth Hospital
RECRUITING
Grand Rapids
Trinity Health Grand Rapids Hospital
RECRUITING
Grand Rapids
Dickinson County Healthcare System
RECRUITING
Iron Mountain
Bronson Methodist Hospital
RECRUITING
Kalamazoo
West Michigan Cancer Center
RECRUITING
Kalamazoo
Minnesota
Minnesota Oncology - Burnsville
RECRUITING
Burnsville
Mercy Hospital
RECRUITING
Coon Rapids
Fairview Southdale Hospital
RECRUITING
Edina
Fairview Clinics and Surgery Center Maple Grove
RECRUITING
Maple Grove
Minnesota Oncology Hematology PA-Maplewood
RECRUITING
Maplewood
Saint John's Hospital - Healtheast
RECRUITING
Maplewood
Abbott-Northwestern Hospital
RECRUITING
Minneapolis
Hennepin County Medical Center
RECRUITING
Minneapolis
Monticello Cancer Center
RECRUITING
Monticello
New Ulm Medical Center
RECRUITING
New Ulm
Fairview Northland Medical Center
RECRUITING
Princeton
Park Nicollet Clinic - Saint Louis Park
RECRUITING
Saint Louis Park
Regions Hospital
RECRUITING
Saint Paul
United Hospital
RECRUITING
Saint Paul
Saint Francis Regional Medical Center
RECRUITING
Shakopee
Lakeview Hospital
RECRUITING
Stillwater
Ridgeview Medical Center
RECRUITING
Waconia
Rice Memorial Hospital
RECRUITING
Willmar
Minnesota Oncology Hematology PA-Woodbury
RECRUITING
Woodbury
Fairview Lakes Medical Center
RECRUITING
Wyoming
Missouri
Parkland Health Center - Farmington
RECRUITING
Farmington
Sainte Genevieve County Memorial Hospital
RECRUITING
Sainte Genevieve
Mercy Hospital Springfield
RECRUITING
Springfield
Mercy Hospital South
RECRUITING
St Louis
Missouri Baptist Medical Center
RECRUITING
St Louis
Missouri Baptist Sullivan Hospital
RECRUITING
Sullivan
BJC Outpatient Center at Sunset Hills
RECRUITING
Sunset Hills
Nevada
Comprehensive Cancer Centers of Nevada - Henderson
RECRUITING
Henderson
Comprehensive Cancer Centers of Nevada-Southeast Henderson
RECRUITING
Henderson
OptumCare Cancer Care at Seven Hills
RECRUITING
Henderson
Urology Specialists of Nevada - Green Valley
RECRUITING
Henderson
Comprehensive Cancer Centers of Nevada - Central Valley
RECRUITING
Las Vegas
Comprehensive Cancer Centers of Nevada - Northwest
RECRUITING
Las Vegas
Comprehensive Cancer Centers of Nevada - Town Center
RECRUITING
Las Vegas
Comprehensive Cancer Centers of Nevada-Summerlin
RECRUITING
Las Vegas
OptumCare Cancer Care at Charleston
RECRUITING
Las Vegas
OptumCare Cancer Care at Fort Apache
RECRUITING
Las Vegas
OptumCare Cancer Care at MountainView
RECRUITING
Las Vegas
Summerlin Hospital Medical Center
RECRUITING
Las Vegas
Urology Specialists of Nevada - Northwest
RECRUITING
Las Vegas
Urology Specialists of Nevada - Southwest
RECRUITING
Las Vegas
New York
Northwell Health/Center for Advanced Medicine
RECRUITING
Lake Success
Ohio
Indu and Raj Soin Medical Center
RECRUITING
Beavercreek
Strecker Cancer Center-Belpre
RECRUITING
Belpre
Saint Elizabeth Boardman Hospital
SUSPENDED
Boardman
Oncology Hematology Care Inc-Kenwood
RECRUITING
Cincinnati
Dayton Physician LLC - Englewood
RECRUITING
Dayton
Armes Family Cancer Center
RECRUITING
Findlay
Blanchard Valley Hospital
RECRUITING
Findlay
Dayton Physicians LLC-Atrium
RECRUITING
Franklin
Wayne Hospital
RECRUITING
Greenville
Greater Dayton Cancer Center
RECRUITING
Kettering
Kettering Medical Center
RECRUITING
Kettering
Marietta Memorial Hospital
RECRUITING
Marietta
Dayton Physicians LLC - Troy
RECRUITING
Troy
Saint Joseph Warren Hospital
SUSPENDED
Warren
Saint Elizabeth Youngstown Hospital
RECRUITING
Youngstown
Oregon
Providence Newberg Medical Center
RECRUITING
Newberg
Providence Willamette Falls Medical Center
RECRUITING
Oregon City
Providence Portland Medical Center
RECRUITING
Portland
Providence Saint Vincent Medical Center
RECRUITING
Portland
South Carolina
Saint Joseph's/Candler - Bluffton Campus
RECRUITING
Bluffton
Gibbs Cancer Center-Gaffney
RECRUITING
Gaffney
Prisma Health Cancer Institute - Butternut
RECRUITING
Greenville
Gibbs Cancer Center-Pelham
RECRUITING
Greer
South Carolina Cancer Specialists PC
RECRUITING
Hilton Head Island
Spartanburg Medical Center
RECRUITING
Spartanburg
SMC Center for Hematology Oncology Union
RECRUITING
Union
Virginia
VCU Community Memorial Health Center
RECRUITING
South Hill
Shenandoah Oncology PC
RECRUITING
Winchester
Washington
PeaceHealth Saint Joseph Medical Center
RECRUITING
Bellingham
PeaceHealth Saint John Medical Center
RECRUITING
Longview
Valley Medical Center
RECRUITING
Renton
PeaceHealth Southwest Medical Center
RECRUITING
Vancouver
Wisconsin
ThedaCare Regional Cancer Center
RECRUITING
Appleton
Aurora Cancer Care-Southern Lakes VLCC
RECRUITING
Burlington
Aurora Saint Luke's South Shore
RECRUITING
Cudahy
HSHS Sacred Heart Hospital
SUSPENDED
Eau Claire
Marshfield Medical Center-EC Cancer Center
RECRUITING
Eau Claire
Aurora Health Care Germantown Health Center
RECRUITING
Germantown
Aurora Cancer Care-Grafton
RECRUITING
Grafton
Aurora BayCare Medical Center
RECRUITING
Green Bay
Saint Vincent Hospital Cancer Center at Saint Mary's
RECRUITING
Green Bay
Saint Vincent Hospital Cancer Center Green Bay
RECRUITING
Green Bay
Aurora Health Center - Greenfield
RECRUITING
Greenfield
Aurora Cancer Care-Kenosha South
RECRUITING
Kenosha
Aurora Bay Area Medical Group-Marinette
RECRUITING
Marinette
Marshfield Medical Center-Marshfield
RECRUITING
Marshfield
Aurora Cancer Care-Milwaukee
RECRUITING
Milwaukee
Aurora Saint Luke's Medical Center
RECRUITING
Milwaukee
Aurora Sinai Medical Center
RECRUITING
Milwaukee
Marshfield Medical Center - Minocqua
RECRUITING
Minocqua
Cancer Center of Western Wisconsin
RECRUITING
New Richmond
Vince Lombardi Cancer Clinic - Oshkosh
RECRUITING
Oshkosh
Aurora Cancer Care-Racine
RECRUITING
Racine
Marshfield Medical Center-Rice Lake
RECRUITING
Rice Lake
Vince Lombardi Cancer Clinic-Sheboygan
RECRUITING
Sheboygan
Marshfield Medical Center-River Region at Stevens Point
RECRUITING
Stevens Point
Saint Vincent Hospital Cancer Center at Sturgeon Bay
RECRUITING
Sturgeon Bay
Aurora Medical Center in Summit
RECRUITING
Summit
Vince Lombardi Cancer Clinic-Two Rivers
RECRUITING
Two Rivers
Aurora Cancer Care-Milwaukee West
RECRUITING
Wauwatosa
Aurora West Allis Medical Center
RECRUITING
West Allis
Marshfield Medical Center - Weston
RECRUITING
Weston
Contact Information
Primary
Ashley Mack, MS
URCC_22063@urmc.rochester.edu
585-275-1090
Time Frame
Start Date: 2023-12-04
Estimated Completion Date: 2031-08-21
Participants
Target number of participants: 800
Treatments
Observational (survey, function tests, biospecimen, actigraph)
Patients complete surveys over 30 minutes, undergo physical function tests over 30 minutes, undergo collection of blood and archived tumor samples, and wear actigraph over 24 hours for 7 days to record daily sleep and exercise activity at baseline and 3-month follow-up. Additionally, patients undergo standard of care PET/CT scans throughout the study and patients' medical records are also reviewed at baseline, 3-month and 1-year follow-up.
Sponsors
Leads: University of Rochester NCORP Research Base
Collaborators: National Cancer Institute (NCI)

This content was sourced from clinicaltrials.gov